Osteocalcin: A new phenomenon for type 2 diabetes and obesity

<b>Objectives: </b>The molecular biology revolution has emerged with the determination that bone tissue is an endocrine organ regulates many physiological processes, and osteocalcin (OCN), osteoblast-derived protein provides control, a hormone glucose energy homeostasis. By controlling gene expression in β-cells adipocytes, OCN improves intolerance, obesity, insulin expression. In addition, stimulates secretion of adiponectin, molecule increases fatty acid oxidation sensitivity adipose reduces accumulation. Recent research suggests serum peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) uncoupling protein-1 (UCP1) genes, which play role thermogenesis brown tissue, it also affects by increasing adiponectin white tissue. target insulin, resting expenditure mitochondrial biogenesis. With all these effects, recently been found to be associated diabetes obesity components.<br /> <b>Conclusions: </b>This review aims present overview understanding interaction produced osteoblasts metabolism, skeletal muscle appetite metabolism functions bone. was conducted examine evaluate relationship pathways affected non-communicable chronic diseases such as type 2 mellitus obesity.